Cerebrospinal fluid with unusual natural killer cell population
نویسندگان
چکیده
منابع مشابه
LIKE T CELL CLONES Brief Definitive Report FUNCTIONAL y CHAIN-ASSOCIATED T CELL RECEPTORS ON CEREBROSPINAL FLUID-DERIVED NATURAL KILLER-
The antigen receptor of most T cells consists of three components, T cell receptor (TCR)-a and -,Q chains and the CD3 (T3) polypeptides (1) . Recently, another receptor has been found (2) on the surface of a small fraction (1-3%) of normal adult peripheral blood T cells . This receptor also consists of three components, TCR-y and -8 chains and the CD3 polypeptides . The function and distributio...
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We have derived 33 independent T cell clones from the cerebrospinal fluid (CSF) of a patient with subacute sclerosing panencephalitis using a single T cell cloning method. 6% (2 of 33) of these clones express the T cell receptor gamma (TCR-gamma) protein and are called CSF TCR-gamma clones. Phenotypic analyses of the CSF TCR-gamma clones indicate that they are WT-31-, CD3+, CD4-, and CD8-. The ...
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Natural killer (NK) cells are part of the innate immune defense against infection and cancer and are especially useful in combating certain viral pathogens. The utility of NK cells in human health has been underscored by a growing number of persons who are deficient in NK cells and/or their functions. This can be in the context of a broader genetically defined congenital immunodeficiency, of wh...
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Lymphoid neoplasms that are derived from natural killer (NK) cells are uncommon but distinct clinicopathologic disease entities. Three types have been recognized and categorized in the latest World Health Organization classification: extranodal NK cell lymphoma, nasal-type; aggressive NK cell leukemia; and blastic NK cell lymphoma. All NK tumor cells express the NK cell marker CD56, but they la...
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ژورنال
عنوان ژورنال: Blood
سال: 2021
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.2020007789